What Do Fecal Calprotectin and Lactoferrin Actually Tell You?

Medically reviewed by our MD Laboratory Director (a role required by CLIA; the director's name is on file in the CMS CLIA database, #45D2048957, and can be verified independently) · Editorial policy
Molecular fluorescence imaging — Auspicious Laboratory, Houston
These markers detect inflammation. They do not name its cause.CLIA #45D2048957 · CAP #8722734 · Same-day results · Walk-ins welcome
They quantify neutrophil-derived proteins in stool — a direct measure of intestinal inflammation. Clinically their greatest value is negative: a low calprotectin in a patient with chronic symptoms argues strongly against active IBD and away from an unnecessary colonoscopy. A high value says "there is inflammation," not "you have Crohn's."
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What raises it

CauseNote
Inflammatory bowel diseaseThe main clinical target
InfectionBacterial gastroenteritis raises it too
NSAIDsA common and frequently overlooked cause
Colorectal neoplasiaPossible; requires appropriate evaluation
IBSTypically normal — this is the useful discrimination

The point of these markers is not to diagnose IBD. It is to tell a physician which patients need a scope and which do not.

We name drugs, never doses. Treatment statements follow ACG, AGA, IDSA and CDC guidance; dose and duration are a physician's decision.
Same day, start to finish. Sample by 1:00 PM → results at 4:30 PM → if treatment is clinically appropriate, a licensed physician in our partner network sees you between 4:30 and 6:00 PM, a few minutes away. That window is reserved for patients tested here, and your slot is held the moment we take your sample — the slot is held, not hunted. On your own, a same-day appointment is nearly impossible; at an urgent care, you wait in the queue. STAT: ~2 hours, sample in by 3:00 PM.

FAQ

Does a high result mean I have Crohn's?
No. It means inflammation. Infection and NSAIDs raise it as well. A gastroenterologist interprets it in context.
Does a normal result rule out IBD?
It makes active IBD much less likely, which is why the test earns its place.
Should I stop NSAIDs before testing?
Tell the physician what you take; they will advise. Do not stop a prescribed medication on your own.
Do you also test for pathogens?
Yes — infection is a common cause of a raised marker, and the molecular panel answers that the same day.
Not sure what you need? Text us and we will set it up.
📱 Text (713) 832-8892 📞 Call (713) 266-0808
3707 Westcenter Dr Suite 100, Houston, TX 77042 · Walk-ins welcome

References

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